p53 both activates and represses gene expression to defend against tumorigenesis. Watch and listen as John Rinn takes you on a brief, personally guided tour of his lab's findings that long intergenic noncoding RNAs mediate the repressive effects of p53. Read more in Huarte et al.
http://www.cell.com/abstract/S0092-8674%2810%2900730-0
Fuente: Cell Press; Broad Institute.
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